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Collagen induction procedures create controlled injury, and that sends a stronger rebuild signal into the dermis, where scar texture begins
Recently, it has been demonstrated that mice with a deletion of the GLP-1 receptor only in -cells, are resistant to the beneficial anti-diabetic effect of a vertical sleeve-gastrectomy ( It appears that only in RYGB and SG patients intestinal derived GLP-1 has a true endocrine role, while in healthy individuals, localized, paracrine and neuronal signals primarily define the GLP-1 physiology
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J Endocr Soc
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